A race to find the best treatment for premature babies at risk for retinopathy of prematurity (ROP) the leading cause of 人妻中出视频hood vision loss and blindness has spurred both controversy and research.
Anti-vascular endothelial growth factor (VEGF) therapies, currently in clinical trials, curb ROP by inhibiting abnormal blood vessel growth in the eye. The problem: VEGF also plays an important role in the development of the retina, and the infant.
"Although clinical trials are testing lower doses of neutralizing VEGF antibodies in severe ROP, a safe and effective dose remains elusive," explains John A. Moran Eye Center's Mary Elizabeth Hartnett, MD, whose work is funded by the and .
Now, new findings from Hartnett and Moran researchers Silke Becker, PhD, and Haibo Wang, PhD, suggest the viability of a different, more selective approach.
The researchers used gene therapy to knockdown overexpressed VEGF in M眉ller cells in the rat model of oxygen-induced retinopathy the most representative model of human ROP. Their findings show targeting VEGF-164 may be effective without being as harmful to the retina as inhibiting VEGF completely.
Scientific Reports published the research, , on Jan. 31, 2018.
The findings are significant as rates of ROP increase along with survival rates for premature infants.
"Additional research must be done, but knowledge like this is getting us closer to better and safer therapies for these babies," said Hartnett.
In addition to Hartnett, the study was conducted by Moran researchers Silke Becker, PhD, Haibo Wang, PhD, and Aaron B. Simmons, PhD. Additional collaborators included Thipparat Suwanmanee, PhD, and Tal Kafri, MD, PhD, from the 人妻中出视频 of North Carolina Chapel Hill, and 人妻中出视频 of Utah Department of Internal Medicine Adjunct Associate Professor Gregory J. Stoddard, MD.